Tissue Engineered Strategies for Skeletal Muscle Injury
نویسندگان
چکیده
منابع مشابه
Tissue Engineered Strategies for Skeletal Muscle Injury
Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management o...
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The potential clinical utility of engineered muscle is currently restricted by limited in vitro capacity of expanded muscle precursor cells to fuse and form mature myofibers. The purpose of this study was to use isotropic skeletal muscle sheets to explore the impact of (1) fibroblast coculture and (2) fibroblast-conditioned media (fCM) on in vitro myogenesis. Muscle sheets were prepared by seed...
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Numerous classification systems of non-union have been proposed based on: presence or absence of infection, radiographic features, clinical findings, biologic activity, location and shape. The management of pseudarthrosis is strongly related to the type of non-union (infected versus uninfected, atrophic versus hypertrophic). Surgical management of pseudarthrosis is generally effective with a su...
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Human bioartificial muscles (HBAMs) are tissue engineered by suspending muscle cells in collagen/MATRIGEL, casting in a silicone mold containing end attachment sites, and allowing the cells to differentiate for 8 to 16 days. The resulting HBAMs are representative of skeletal muscle in that they contain parallel arrays of postmitotic myofibers; however, they differ in many other morphological ch...
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INTRODUCTION Engineered tissues offer strong possibilities as model systems for studying tissue responses to physical, chemical or biological stimuli. Moreover, they can be used to investigate specific pathologies or clinical treatments with less ethical considerations and better experimental control than animal models or human studies. We use the concept of tissue engineering to design in-vitr...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2012
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2012/175038